liprin-alpha-1; LAR-interacting protein 1; LIP-1; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; PTPRF-interacting protein alpha-1 (PPFIA1, LIP1)

Function

• may regulate disassembly of focal adhesions
• may localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment & their association with substrates
• phosphorylated upon DNA damage, probably by ATM or ATR
• forms homodimers & heterodimers with liprins-alpha & liprins-beta
• interacts with the second PTPase domain of PTPRD, PTPRF & PTPRS
• interacts with GIT1, KIF1A & GRIP1

Structure

• the N-terminal coiled coil regions mediate homodimerization preferentially & heterodimerization type alpha/alpha
• the C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta & interaction with PTPRD, PTPRF & PTPRS
• belongs to the liprin family, liprin-alpha subfamily
• contains 3 SAM (sterile alpha motif) domains

Compartment

• cytoplasm
• colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus

Alternative splicing

• named isoforms=2
• intron retention

Expression

ubiquitous

More general terms

• liprin-alpha

Additional terms

• receptor-type tyrosine-protein phosphatase F; Leukocyte common antigen related; LAR (PTPRF, LAR)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8500
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8500
• OMIM: https://mirror.omim.org/entry/611054
• UniProt: http://www.uniprot.org/uniprot/Q13136.html