receptor-type tyrosine-protein phosphatase S; R-PTP-S; receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma (PTPRS)

Function

• interacts with LAR-interacting protein LIP.1
• undergoes 'ectodomain shedding'
• interacts with PPFIA1, PPFIA2 & PPFIA3

protein tyrosine phosphate + H2O = protein tyrosine + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family receptor class 2A subfamily
• contains 8 fibronectin F3 modules
• contains 3 Ig-like C2-type domains
• contains 2 tyrosine-protein phosphatase domains

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

• named isoforms=7
• additional isoforms seem to exist

Expression

• expressed in most tissues
• not expressed in placenta & liver

More general terms

• tyrosine phosphatase, receptor type
• receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5802
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5802
• OMIM: https://mirror.omim.org/entry/601576
• UniProt: http://www.uniprot.org/uniprot/Q13332.html