receptor-type tyrosine-protein phosphatase F; Leukocyte common antigen related; LAR (PTPRF, LAR)

Function

• possible cell adhesion receptor
• possesses an intrinsic protein tyrosine phosphatase activity (PTPase)
• the first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one
• interacts with GRIP1 (putative). interacts with PPFIA1, PPFIA2 & PPFIA3

protein tyrosine phosphate + H2O = protein tyrosine + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family receptor class 2A subfamily
• contains 8 fibronectin F3 modules
• contains 3 Ig-like C2-type domains
• contains 2 tyrosine-protein phosphatase domains

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

More general terms

• tyrosine phosphatase, receptor type
• glycoprotein
• adhesion receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5792
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5792
• OMIM: https://mirror.omim.org/entry/179590
• UniProt: http://www.uniprot.org/uniprot/P10586.html