rab3A proto-oncogene protein; small GTP-binding protein 25A; Ras-related protein Rab-3A (RAB3A, smg p25A)
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Function
- role in exocytosis via regulating a late step in synaptic vesicle fusion
- role in neurotransmitter release via regulating membrane flow in the nerve terminal
- regulation of secretion at brain synapses (neurotransmitter release) & from endocrine & exocrine cells
- heterodimer with RIMS2
- part of a ternary complex involving PCLO & EPAC2
- interacts with RPH3A
- interacts with the exocyst complex through SEC15
- binds SYTL4, RIMS1 & RIMS2
- interacts with RAB3IP
- interacts with SGSM1 & SGSM3
Structure
belongs to the small GTPase superfamily, Rab family
Compartment
- cell membrane; lipid-anchor; cytoplasmic side (putative)
Expression
specifically expressed in brain
More general terms
References
- ↑ Matsui Y et al Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP- binding protein. Mol Cell Biol 1990 Aug;10(8):4116-22 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2115118
- ↑ Mizoguchi A et al Localization and subcellular distribution of smg p25A, a ras p21-like GTP-binding protein, in rat brain. J Biol Chem 1990 Jul 15;265(20):11872-9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2114404
- ↑ OMIM https://mirror.omim.org/entry/179490
- ↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
- ↑ Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209
- ↑ Seabra MC et al Rab GTPases, intracellular traffic and disease Trends in Molecular Medicine 8:23, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11796263
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5864
- ↑ UniProt http://www.uniprot.org/uniprot/P20336.html