synaptotagmin-like protein 4; exophilin-2; granuphilin (SYTL4)

Function

• modulates exocytosis of dense-core granules
• secretion of hormones in the pancreas & pituitary
• interacts with vesicles containing negatively charged phospholipids (Ca+2-independent)
• component of ternary complex containing STX1A, RAB27A
• binds RAB27A, STXBP1, RAB3A, RAB8A, RAB27B

Structure

• contains 2 C2 domains
• contains 1 FYVE-type Zn+2 finger
• contains 1 RabBD (Rab-binding) domain

Compartment

• peripheral membrane, plasma membrane, on secretory granules
• in pancreas, interacts with insulin-containing vesicles

Alternative splicing

named isoforms=2

More general terms

• synaptotagmin-like protein (SYTL)
• exophilin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=94121
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:94121
• UniProt: http://www.uniprot.org/uniprot/Q96C24.html