wee1 proto-oncogene protein

^[1]^[2]^[3]

Function

promotes inhibitory phosphorylation of p34cdc2 (CDK1) subunit of MPF on T14 & Y15 in yeast, only of Y15 in human (apparently a separate serine/threonine kinase phosphorylates T14 of CDK1 & CDK2)

↑ Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell. 1991 Oct 4;67(1):197-211. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1913817
↑ Parker LL, Piwnica-Worms H. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science. 1992 Sep 25;257(5078):1955-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1384126
↑ Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9;374(6518):131-4. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7877684