F-box/WD repeat-containing protein 2; F-box & WD-40 domain-containing protein 2; protein MD6 (FBXW2, FBW2, FWD2)

Function

• substrate-recognition component of the SCF complex
• interacts directly with SKP1A & CUL1

Structure

• contains 1 F-box domain
• contains 4 WD repeats

Alternative splicing

named isoforms=2

More general terms

• F-box & WD-repeat protein

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26190
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26190
• OMIM: https://mirror.omim.org/entry/609071
• UniProt: http://www.uniprot.org/uniprot/Q9UKT8.html