CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; transcriptional repressor NOT4Hp (CNOT4, NOT4)

Function

• E3 ubiquitin ligase
• subunit of the CCR4-NOT core complex
• protein modification; protein ubiquitination
• autoubiquitinated
• phosphorylated upon DNA damage, probably by ATM or ATR
• binds CNOT1 via its C-terminus
• binds E2 ubiquitin ligases via its RING domain
• interacts (via RING domain) with UBE2D2

Structure

• contains 1 C3H1-type Zn+2 finger
• contains 1 RING-type Zn+2 finger
• contains 1 RRM domain (RNA recognition motif)

Compartment

• cytoplasm (probable)
• nucleus (probable)

Alternative splicing

named isoforms=8

More general terms

• E3 ubiquitin ligase
• protein subunit
• RNA-binding protein
• transcriptional silencer (transcriptional repressor)
• ring finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4850
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4850
• OMIM: https://mirror.omim.org/entry/604911
• UniProt: http://www.uniprot.org/uniprot/O95628.html