CCR4-NOT core complex

Introduction

Ubiquitous general transcription regulation complex.

Function

• one of the major cellular mRNA deadenylases
• linked to various cellular processes including
  • bulk mRNA degradation
  • miRNA-mediated repression
  • translational repression during translational initiation
  • general transcription regulation.

Structure

• subunits include:
  • CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6, CNOT6L, CNOT7, CNOT8, CNOT9, CNOT10, CNOT11, TNKS1BP1
• distinct complexes seem to exist that differ in probably mutually exclusive catalytic subunits

Expression

ubiquitous

More general terms

• molecular complex