CCR4-NOT transcription complex subunit 1 (negative regulator of transcription subunit 1 homolog, NOT1H, hNOT1, CCR4-associated factor 1, CNOT1, CDC39, KIAA1007, NOT1, AD-005)

Function

• belongs to the CCR4-NOT complex
• acts as a transcriptional repressor
• represses the ligand-dependent transcriptional activation by nuclear receptors
• interacts in a ligand-dependent fashion with ESR1 & RXRA

Structure

belongs to the CNOT1 family

Alternative splicing

named isoforms=4

Expression

• strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta & lung
• weakly expressed in skeletal muscle & colon

More general terms

• protein subunit
• transcriptional silencer (transcriptional repressor)

Component of

• CCR4-NOT core complex

Database

• OMIM: https://mirror.omim.org/entry/604917
• UniProt: http://www.uniprot.org/uniprot/A5YKK6.html