182 kD tankyrase-1-binding protein (TNKS1BP1, KIAA1741, TAB182)

Function

• ADP-ribosylated by TNKS1 (in vitro)
• phosphorylated upon DNA damage, probably by ATM or ATR
• binds to the ANK repeat domain of TNKS1 & TNKS2

Compartment

• nucleus, cytoplasm, cytoskeleton, chromosome
• colocalizes with chromosomes during mitosis, & in the cytoplasm with cortical actin

Alternative splicing

named isoforms=2

Expression

• expressed in testis, ovary, lung, skeletal muscle, heart, prostate & pancreas
• expressed at very low levels in brain & peripheral blood leukocytes

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85456
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85456
• OMIM: https://mirror.omim.org/entry/607104
• UniProt: http://www.uniprot.org/uniprot/Q9C0C2.html