CCR4-NOT transcription complex subunit 6-like (carbon catabolite repressor protein 4 homolog B, CNOT6L, CCR4B)

Function

• role in the deadenylation of mRNAs in cytoplasm
• has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate.
• may be involved in deadenylation-dependent degradation of mRNAs through the 3'UTR AU-rich element-mediated mechanism
• involved in deadenylation-dependent degradation of CDKN1B mRNA
• component of the CCR4-NOT complex

Structure

• belongs to the CCR4/nocturin family
• contains 3 LRR repeats (leucine-rich repeats)

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• highly expressed in placenta, skeletal muscle, pancreas, testis & leukocytes
• weakly expressed in heart, spleen & thymus

Pathology

depletion of CNOT6L causes cell growth defect

More general terms

• exoribonuclease

Component of

• CCR4-NOT core complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q96LI5.html