CCR4-NOT transcription complex subunit 6 (cytoplasmic deadenylase, carbon catabolite repressor protein 4 homolog, CCR4 carbon catabolite repression 4-like, CNOT6, CCR4, KIAA1194)

Function

• poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm
• 3'-5' RNase activity
• subunit of the CCR4-NOT core complex
• interacts with UNR

Cofactor: Mg+2

Structure

• belongs to the CCR4/nocturin family
• contains 3 LRR repeats (leucine-rich repeats)

Expression

nucleus, cytoplasm

More general terms

• protein subunit

Component of

• CCR4-NOT core complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5747
• OMIM: https://mirror.omim.org/entry/608951
• UniProt: http://www.uniprot.org/uniprot/Q9ULM6.html