CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2, CNOT2, CDC36, NOT2, HSPC131, MSTP046)

Function

• subunit of the CCR4-NOT core complex
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the CNOT2/3/5 family

Compartment

cytoplasm, nucleus (probable)

Alternative splicing

named isoforms=5

Expression

• ubiquitous
• highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung & peripheral blood leukocytes

More general terms

• protein subunit
• phosphoprotein

Component of

• CCR4-NOT core complex

Database

• OMIM: https://mirror.omim.org/entry/604909
• UniProt: http://www.uniprot.org/uniprot/Q9NZN8.html