E3 ubiquitin-protein ligase Praja2 (Praja-2, RING finger protein 131, PJA2, KIAA0438, RNF131)

Function

• E2-dependent E3 ubiquitin-protein ligase activity
• ubiquitin conjugation, 3rd step
• binds ubiquitin-conjugating enzymes (E2)
• in vitro, interacts with ubiquitin-conjugating enzyme, UBE2D2

Structure

contains 1 RING-type zinc finger

Compartment

• cytoplasm
• endoplasmic reticulum (ER) membrane
• peripheral membrane
• Golgi membrane
• cell junction, synapse, postsynaptic density
• localizes at cytoplasmic side of ER & Golgi
• expressed in postsynaptic density region of synapses

Alternative splicing

named isoforms=2

More general terms

• ring finger protein
• E3 ubiquitin ligase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/O43164.html