CD49d (integrin alpha-4, VLA-4 alpha chain, ITGA4)
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Function
- associates with integrin beta-1 (integrin alpha-4/beta-1) & integrin beta-7 (integrin alpha-4/beta-7)
- can sometimes be cleaved into two non-covalently associated fragments
- interacts with PXN, LPXN, & TGFB1I1/HIC5
- interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan
- phosphorylation on Ser-1027 inhibits PXN binding
- mportant for generation of neurites & in neuronal plasticity[2]
Structure
- the SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan & cell adhesion
- belongs to the integrin alpha chain family
- contains 7 FG-GAP repeats
Compartment
membrane
More general terms
Component of
References
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
- ↑ Jump up to: 2.0 2.1 Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG, Tsien JZ, Hu Y. Effects of environmental enrichment on gene expression in the brain. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11070096
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3676
- ↑ UniProt http://www.uniprot.org/uniprot/P13612.html