very late antigen 4 (VLA-4, integrin alpha-4/beta-1)

Function

• receptor for fibronectin, VCAM1 & laminin ?
• recognizes one or more domains within the alternatively spliced CS-1 & CS-5 regions of fibronectin
• recognizes the sequence Q-I-D-S in VCAM1
• on activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines
• it may also participate in cytolytic T-cell interactions with target cells

Subunits

integrin alpha-4, integrin beta-1

Compartment

membrane

More general terms

• CD49 or Very Late Antigen (VLA)

Additional terms

• fibronectin; FN; cold-insoluble globulin; CIG; contains: anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3 (FN1, FN)
• laminin