vascular cell adhesion protein 1; V-CAM 1; INCAM-100; CD106 (VCAM1, L1CAM)

Function

• cell-cell recognition
• leukocyte migration/leukocyte-endothelial cell adhesion
• interact with integrins alpha-4/beta-1 (VLA4) on leukocytes

Structure

• either 1st or the 4th Ig-like C2-type domain is required for VLA4-dependent cell adhesion
• contains 7 Ig-like C2-type domains (immunoglobulin-like)

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2 comment=additional isoforms seem to exist

Expression

• macrophage-like and dendritic cell types
• inflamed vascular endothelium
• induced by cytokines, including IL-1, TNF-alpha

Pathology

• may play role in
  • atherosclerosis
  • rheumatoid arthritis

Laboratory

• vascular cell adhesion molecule 1 in serum/plasma

More general terms

• CD antigen
• glycoprotein
• adhesion receptor

Database

• UniProt: http://www.uniprot.org/uniprot/P19320.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7412
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7412
• OMIM: https://mirror.omim.org/entry/192225