Rho guanine nucleotide exchange factor 6; alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6 (ARHGEF6, COOL2, KIAA0006, PIXA)

Function

• acts as a RAC1 guanine nucleotide exchange factor (GEF)
• interacts with PAK kinases through the SH3 domain
• interacts with GIT1
• component of cytoplasmic complexes, which also contain PXN, GIT1 & PAK1 (putative)

Structure

• contains 1 CH (calponin-homology) domain
• contains 1 DH (DBL-homology) domain
• contains 1 PH domain
• contains 1 SH3 domain

Alternative splicing

named isoforms=2

Expression

ubiquitous

Pathology

• defects in ARHGEF6 are the cause of mental retardation X-linked type 46

More general terms

• rho guanine nucleotide exchange factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9459
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9459
• OMIM: https://mirror.omim.org/entry/300267
• OMIM: https://mirror.omim.org/entry/300436
• UniProt: http://www.uniprot.org/uniprot/Q15052.html