p21 (CDKN1A)-activated kinase (PAK)

Function

• Rho family GTPases bind to & activate PAKs
• PAK proteins have been implicated as downstream effectors linking Rho GTPases to the actin cytoskeleton & to effectors of MAP kinase cascades, including JNK1 & MAP kinase p38 alpha

More general terms

• serine/threonine kinase

More specific terms

• p21 Cdc42(rho-G)/Rac-associated kinase, PAK1, p65PAK or alpha-PAK
• p21-activated kinase 2 (PAK2), S6/H4 kinase, PAK65 or gamma-PAK
• p21-activated kinase 3 (PAK3), beta-PAK or oligophrenin-3
• p21-activated kinase 4 (PAK4, serine/threonine protein kinase PAK 4, KIAA1142)
• p21-activated kinase 5; p21-activated kinase 7; serine/threonine protein kinase PAK5; p21-activated kinase 7 (PAK7, PAK5)
• p21-activated kinase 6 (PAK6)