p21-activated kinase 5; p21-activated kinase 7; serine/threonine protein kinase PAK5; p21-activated kinase 7 (PAK7, PAK5)

Function

• activated kinase acts on a variety of targets
• interacts tightly with GTP-bound but not GDP-bound CDC42/p21 & RAC1 (putative)
• autophosphorylated when activated by CDC42/p21

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 CRIB domain
• contains 1 protein kinase domain

Expression

predominantly expressed in brain

More general terms

• p21 (CDKN1A)-activated kinase (PAK)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5714
• OMIM: https://mirror.omim.org/entry/608038
• UniProt: http://www.uniprot.org/uniprot/Q9P286.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57144