p21-activated kinase 3 (PAK3), beta-PAK or oligophrenin-3

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Function

Structure

Alternative splicing

named isoforms=2

Expression

Pathology

d

  • defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/O75914.html
  2. 2.0 2.1 Boda B, Alberi S, Nikonenko I, Node-Langlois R, Jourdain P, Moosmayer M, Parisi-Jourdain L, Muller D. The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus. J Neurosci. 2004 Dec 1;24(48):10816-25. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15574732
  3. 3.0 3.1 Meng J, Meng Y, Hanna A, Janus C, Jia Z. Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci. 2005 Jul 13;25(28):6641-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16014725
  4. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=PAK3

Database