p21-activated kinase 3 (PAK3), beta-PAK or oligophrenin-3
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Function
- plays a role in hippocampal synaptogenesis & synaptic plasticity[3]
- phosphorylates LIM kinase
- activity may be stimulated by GSK3-beta
- binds to GTP-bound Cdc42hs & rac1
- binding of GTP-bound CDC42 or rac1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 & allows kinase domain to adopt an active structure
- autophosphorylated when activated by CDC42/p21
- binds to SH3 domains of PLC-gamma & NCK adaptor protein
Structure
- belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
- contains 1 CRIB domain
- contains 1 protein kinase domain
Alternative splicing
named isoforms=2
Expression
Pathology
d
- defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O75914.html
- ↑ 2.0 2.1 Boda B, Alberi S, Nikonenko I, Node-Langlois R, Jourdain P, Moosmayer M, Parisi-Jourdain L, Muller D. The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus. J Neurosci. 2004 Dec 1;24(48):10816-25. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15574732
- ↑ 3.0 3.1 Meng J, Meng Y, Hanna A, Janus C, Jia Z. Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci. 2005 Jul 13;25(28):6641-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16014725
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=PAK3