leukocyte immunoglobulin-like receptor subfamily B member 3; leukocyte immunoglobulin-like receptor 3; LIR-3; immunoglobulin-like transcript 5; ILT-5; monocyte inhibitory receptor HL9; CD85 antigen-like family member A; CD85a (LILRB3, ILT5, LIR3)

Function

• may act as receptor for class 1 MHC antigens

Structure

• contains 3 ITIM motifs
• phosphorylated ITIM motif can bind the SH2 domain of several SH2 domain-containing phosphatases
• contains 4 Ig-like C2-type domains (immunoglobulin-like)

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

Expression

• detected in monocytes & B-cells

Genetics

• belongs to the leukocyte receptor cluster (LRC) present on chromosome 19q13.4

More general terms

• CD85 or leukocyte immunoglobulin-like receptor family protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604820
• UniProt: http://www.uniprot.org/uniprot/O75022.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11025