leukocyte surface antigen CD47; integrin-associated protein; IAP; antigenic surface determinant protein OA3; protein MER6; CD47 (CD47, MER6)

^[1]^[2]^[3]^[4]

Function

thrombospondin receptor
role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, & in modulation of integrins
role in memory formation & synaptic plasticity in the hippocampus (putative)
receptor for SIRPA, binding to which prevents maturation of immature dendritic cells & inhibits cytokine production by mature dendritic cells
interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation & costimulates T-cell activation
may play a role in membrane transport &/or integrin dependent signal transduction
may prevent premature elimination of red blood cells
may be involved in membrane permeability changes induced following virus infection
interacts with THBS1 & fibrinogen (putative)
interacts with SIRPA, SIRPG, UBQLN1 & UBQLN2

named isoforms=4
at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

expressed in:
- misc tumor cell lines
- ovarian tumors
CD47 expression on the surface of cancer cells may help them evade to immune system^[4]