signal-regulatory protein gamma; SIRP-gamma; CD172 antigen-like family member B; signal-regulatory protein beta-2; SIRP-b2; SIRP-beta-2; CD172g (SIRPG, SIRPB2)
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Function
- probable immunoglobulin-like cell surface receptor
- on binding with CD47, mediates cell-cell adhesion
- engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation & costimulates T-cell activation
- interacts with CD47
Structure
- contains 2 Ig-like C1-type domains (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment
membrane
Alternative splicing
named isoforms=4
Expression
- detected in liver, & at very low levels in brain, heart, lung, pancreas, kidney, placenta & skeletal muscle
- expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer cells (NK cells), CD20+ cells, & all activated NK cells
- mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle & in the germinal center of B-cell follicles
- in the thymus, primarily expressed in the medulla on mature T lymphocytes that have undergone thymic selection