CD56; neural cell adhesion molecule 1; NCAM-1 (NCAM1, NCAM)
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Function
- regulates interactions between neurons & between neurons & muscle
- associates with fibroblast growth factor receptor & stimulates tyrosine kinase activity to induce neurite outgrowth
Structure
- contains 2 fibronectin F3 modules
- contains 5 Ig-like C2-type domains (immunoglobulin-like)
Compartment
- secreted
- isoforms 1,2: cell membrane, transmembrane domain
- isoform 3,4: cell membrane; lipid-anchor, GPI-anchor
- isoforms 5,6: secreted
Alternative splicing
named isoforms=6
Expression
- NK cells ~80 - 90%
- activated T cells
- brain, cerebellum
- neuromuscular junctions
- neuroendocrine tissues
Pathology
- expressed in:
- primitive neuroectodermal tumors (PNETs) stain negatively with antibody.
More general terms
References
- ↑ Baron M, Norman DG, Campbell ID. Protein modules. Trends Biochem Sci. 1991 Jan;16(1):13-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053133
- ↑ Schachner M, Martini R. Glycans and the modulation of neural-recognition molecule function. Trends Neurosci. 1995 Apr;18(4):183-91. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7539963 (HNK-I)
- ↑ http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Wikipedia: Neural cell adhesion molecule http://en.wikipedia.org/wiki/Neural_cell_adhesion_molecule
- ↑ UniProt http://www.uniprot.org/uniprot/P13591.html
- ↑ Functional glycomics gateway - glycan binding - N-CAM 140 http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Itlect_264