leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor 2; LIR-2; immunoglobulin-like transcript 4; ILT-4; monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD85 antigen-like family member D; CD85d (LILRB2, ILT4, LIR2, MIR10)

Function

• receptor for class 1 MHC antigens
• recognizes a broad spectrum of HLA-A, HLA-B, HLA-C & HLA-G alleles
• involved in down-regulation of the immune response & development of tolerance
• competes with CD8A for binding to class 1 MHC antigens
• inhibits FCGR1A-mediated phosphorylation of cellular proteins & mobilization of intracellular Ca+2
• phosphorylated on Tyr
• dephosphorylated by PTPN6
• binds PTPN6 when phosphorylated
• binds FCGR1A

Structure

• contains 3 ITIM motifs
• phosphorylated ITIM motif can bind the SH2 domain of several SH2 domain-containing phosphatases
• contains 4 Ig-like C2-type domains

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

Expression

• expressed on monocytes & B-cells
• lower levels on dendritic cells
• detected at low levels in NK cells

More general terms

• CD85 or leukocyte immunoglobulin-like receptor family protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10288
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10288
• OMIM: https://mirror.omim.org/entry/604815
• UniProt: http://www.uniprot.org/uniprot/Q8N423.html