Fc receptor-like protein 4 (FcR-like protein 4, FcRL4, Fc receptor homolog 4, FcRH4, IFGP family protein 2, hIFGP2, immune receptor translocation-associated protein 1, FCRL4, FCRH4, IFGP2, IRTA1)

Function

• may function as an inhibitor of B cell receptor signaling
• may function in the B cell-mediated immune response
• phosphorylated on cytoplasmic tyrosines upon activation

Structure

contains 4 Ig-like C2-type domain (immunoglobulin-like)

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

• specifically expressed by memory & monocytoid B cells which populate spleen & lymph nodes
• preferentially expressed in memory B cells associated with mucosal tissue (at protein level)

Pathology

• chromosomal translocation t(1;1)(p36.3;q21.1-2) involving FCRL4 is found in non-Hodgkin lymphoma
• chromosomal translocation t(1;14)(q21;q32) involving FCRL4 is found in multiple myeloma. translocation forms a FCRL4-IGHA1 fusion protein

More general terms

• glycoprotein
• Fc receptor
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8341
• OMIM: https://mirror.omim.org/entry/605876
• UniProt: http://www.uniprot.org/uniprot/Q96PJ5.html