CD84 leukocyte antigen; SLAM family member 5 precursor; signaling lymphocytic activation molecule 5; cell surface antigen MAX.3; Hly9-beta (SLAMF5)

Function

• homophilic clustering adhesion molecule
  • enhances interferon gamma secretion in lymphocytes
• recruits SH2 domain-containing proteins SH2D1A/SAP
• increases proliferative responses of activated T-cells
  • SH2D1A/SAP does not seen be required
• induces platelet stimulation (SH2D1A/SAP-dependent)
• marker for hematopoietic progenitor cells
• interacts with SH2 domain-containing proteins SH2D1A/SAP & SH2D1B/hEAT-2
• interaction with tyrosine-protein phosphatases PTPN6 & PTPN11 via its phosphorylated cytoplasmic domain, blocked by SH2D1A
• ITSM motif may bind SH2D1A
• phosphorylated by tyrosine-protein kinase LCK on Tyr following ligation induced by agonist monoclonal antibody
• association with SH2D1A/SAP is dependent on Tyr phosphorylation of its cytoplasmic domain
• phosphorylated on Tyr-296 & Tyr-316 following platelet aggregation

Structure

• homooligomer, via its extracellular domain
• N-glycosylated
• contains 1 Ig-like C2-type domain (immunoglobulin-like)

Compartment

- cell membrane

Alternative splicing

named isoforms=7

Expression

• predominantly expressed in hematopoietic tissues, including lymph nodes, spleen, peripheral leukocytes.
• expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells, dentritic cells
• highly expressed in memory T-cells
• expression is slightly increased in naive B-cells after 1st division
• in contrast, expression on memory B-cells decreased with each successive division

More general terms

• CD antigen
• immunoglobulin superfamily protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604513
• UniProt: http://www.uniprot.org/uniprot/Q9UIB8.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8832