CMRF35-like-molecule 1 (CLM-1, immune receptor expressed on myeloid cells protein 1, IREM-1, immunoglobulin superfamily member 13, IgSF13, NK inhibitory receptor, CD300 antigen-like family member F, CD300LF, CLM1, IGSF13, IREM1, NKIR, UNQ3105/PRO10111)

Function

• receptor which may be involved in functional regulation of myeloid cells
• inhibits osteoclast formation
• interacts with PTPN6/SHP-1 (Tyr phosphorylation-dependent)
• phosphorylated on Tyr

Structure

contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=6

Expression

• highly expressed in spleen, peripheral blood leukoctes, monocytes, lung
• weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, colon
• expressed selectively in monocytes & monocyte-related cells

More general terms

• immunoglobulin superfamily protein
• cell surface receptor
• CD300 family protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TDQ1.html