Fc receptor-like protein 2; FcR-like protein 2; FcRL2; Fc receptor homolog 2; FcRH2; IFGP family protein 4; immunoglobulin receptor translocation-associated protein 4; SH2 domain-containing phosphatase anchor protein 1; CD307b (FCRL2, FCRH2, IFGP4, IRTA4, SPAP1, UNQ9236/PRO31998)

Function

• regulatory role in normal & neoplastic B cell development
• tyrosine-phosphorylated isoform 2 interacts with PTPN6

Structure

• type 1 membrane protein
• contains 2-4 ITIM motifs
• phosphorylated ITIM motif binds SH2 domain of PTPN6
• contains 4 Ig-like C2-type domains
• isoform 2 is N-glycosylated & O-glycosylated

Compartment

• cell membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=5

Expression

• expressed in the secondary lymphoid organs, spleen, lymph node
• expression limited to mature B cells, CD19 +

More general terms

• cell surface receptor
• glycoprotein
• immunoglobulin superfamily protein
• CD antigen

Additional terms

• Fc receptor-like B (Fc receptor-like protein 2, Fc receptor-like & mucin-like protein 2, Fc receptor-related protein Y, FcRY, Fc receptor homolog expressed in B cells protein 2, FREB-2, FCRLB, FCRL2, FCRLM2, FCRY, FREB2)
• PAPA syndrome; pyogenic sterile arthritis, pyoderma gangrenosum, & acne; familial recurrent arthritis

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79368
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79368
• OMIM: https://mirror.omim.org/entry/606509
• UniProt: http://www.uniprot.org/uniprot/Q96LA5.html