poly [ADP-ribose] polymerase 2; PARP-2; hPARP-2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; poly[ADP-ribose] synthase 2; pADPRT-2 (PARP2 ADPRT2 ADPRTL2)

Introduction

Also see poly[ADP-ribose]polymerase

Function

• role in the base excision repair pathway, by catalyzing poly-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture & in DNA metabolism
• poly-ADP-ribosylation follows DNA damage & appears as an obligatory step in a detection/signaling pathway leading to repair of DNA double-strand breaks
• poly-ADP-ribosylated by PARP1 (putative)
• component of a base excision repair complex
• homodimer & heterodimer with PARP1

Structure

• contains 1 PARP alpha-helical domain
• contains 1 PARP catalytic domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• widely expressed, mainly in actively dividing tissues
• highest levels are in the brain, heart, pancreas, skeletal muscle & testis
• also detected in kidney, liver, lung, placenta, ovary & spleen
• low expression in leukocytes, colon, small intestine, prostate & thymus

More general terms

• NAD+ ADP-ribosyltransferase or poly ADP-ribose polymerase

Additional terms

• poly(ADP-ribose)glycohydrolase (pARG)

Component of

• base excision repair (BER) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10038
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10038
• OMIM: https://mirror.omim.org/entry/607725
• UniProt: http://www.uniprot.org/uniprot/Q9UGN5.html