chromodomain-helicase-DNA-binding protein 1-like (amplified in liver cancer protein 1, CHD1L, ALC1)

Function

• putative DNA helicase, which may play a role in chromatin-remodeling
  • in vitro, promotes cell proliferation & inhibits apoptois

Structure

• belongs to the SNF2/RAD54 helicase family
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain
• contains 1 macro domain

Compartment

nucleus

Alternative splicing

named isoforms=4

Expression

• frequently overexpressed in hepatomacellular carcinomas

More general terms

• enzyme
• nuclear protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9557
• UniProt: http://www.uniprot.org/uniprot/Q86WJ1.html