histone-lysine N-methyltransferase SUV39H2; histone H3-K9 methyltransferase 2; H3-K9-HMTase 2; lysine N-methyltransferase 1B; suppressor of variegation 3-9 homolog 2; Su(var)3-9 homolog 2 (SUV39H2, KMT1B)
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Function
- histone methyltransferase
- specifically trimethylates Lys-9 of histone H3 using monomethylated H3 Lys-9 as substrate
- H3 Lys-9 trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 &/or CBX5) proteins to methylated histones
- mainly functions in heterochromatin regions, thus playing a role in the establishment of constitutive heterochromatin at pericentric & telomere regions
- H3 Lys-9 trimethylation is also required to direct DNA methylation at pericentric repeats
- targeted to histone H3 via its interaction with RB1
- SUV39H1 is involved in many processes, such as
- cell cycle regulation
- transcriptional repression
- regulation of telomere length
- may participate in regulation of higher order chromatin organization during spermatogenesis
- interacts with SMAD5
S-adenosyl-L-methionine + L-lysine-[[[A137031|histone]]] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[[[A137031|histone]]]
Structure
- although the SET domain contains the active site, both pre-SET & post-SET domains are required for methyltransferase activity
- the SET domain also participates in stable binding to heterochromatin (putative)
- belongs to the histone-lysine methyltransferase family, Suvar3-9 subfamily
- contains 1 chromo domain
- contains 1 post-SET domain
- contains 1 pre-SET domain
- contains 1 SET domain
Compartment
- nucleus, chromosome, centromere
- associates with centromeric constitutive heterochromatin (putative)
Alternative splicing
named isoforms=3