SMAD9/MADH9; mothers against decapentaplegic homolog 9; mothers against DPP homolog 9; MAD homolog 9; SMAD family member 9; SMAD 9; smad9; Madh6 (SMAD9, MADH6, MADH9)

Function

• transcriptional modulator
• activated by BMP type 1 receptor kinase
• SMAD9 is a receptor-regulated SMAD (R-SMAD)
• phosphorylated on Ser by BMP type 1 receptor kinase
• interaction with the co-SMAD SMAD4
• interacts with PEBP2-alpha subunit

Structure

• belongs to the dwarfin/SMAD family
• contains 1 MH1 (MAD homology 1) domain
• contains 1 MH2 (MAD homology 2) domain

Compartment

• cytoplasm (putative), nucleus
• cytoplasmic in the absence of ligand
• migration to the nucleus when complexed with SMAD4

Alternative splicing

• named isoforms=2; A, B

Expression

• expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary & small intestine
• also expressed in fetal brain, lung & kidney

More general terms

• SMAD protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4093
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4093
• OMIM: https://mirror.omim.org/entry/603295
• UniProt: http://www.uniprot.org/uniprot/O15198.html