beta-fodrin; spectrin beta chain, brain 1; spectrin, non-erythroid beta chain 1; beta-II spectrin; Fodrin beta chain (SPTBN1, SPTB2)

Function

• phosphorylated on Ser-8 (putative), Ser-10 & Ser-14
• isoform 2 is phosphorylated on Ser-8 & Ser-10
• the short form cannot bind to the axonal protein fodaxin
• interacts with ANK2

Structure

• belongs to the spectrin family
• contains 2 CH (calponin-homology) domains
• contains 1 PH domain
• contains 17 spectrin repeats

Compartment

• cytoplasm, cytoskeleton
• myofibril, sarcomere, M-band (putative)
• colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes (putative)
• isoform 2:
  • cell membrane
  • peripheral membrane protein; cytoplasmic side (putative)

Alternative splicing

named isoforms=3; long, short

Expression

• isoform 2 is present in brain, lung & kidney (at protein level)

More general terms

• protein subunit

Component of

• fodrin (non erythrocytic spectrin)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6711
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6711
• OMIM: https://mirror.omim.org/entry/182790
• UniProt: http://www.uniprot.org/uniprot/Q01082.html