fodrin (non erythrocytic spectrin)

Function

• seems to be involved in secretion
• interacts with calmodulin (Ca+2-dependent)
• Ca+2-dependent movement of the cytoskeleton at the membrane (putative)
• phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro (putative)
• like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers

Compartment

• cytoplasm, cytoskeleton
• cell membrane
• peripheral membrane protein; cytoplasmic side (putative)

More general terms

• membrane protein
• cytoskeletal protein
• calmodulin binding protein
• PEST protein
• multisubunit protein