TBC1 domain family member 10A; EBP50-PDX interactor of 64 kD; EPI64 protein; Rab27A-GAP-alpha (TBC1D10A, EPI64, TBC1D10)

Function

• GTPase-activating protein for RAB27A
  • no GTPase-activating for RAB2A, RAB3A, nor RAB4A
• binds to the first PDZ domain of SLC9A3R1 & SLC9A3R2
• phosphorylated

Structure

• the arginine & glutamine fingers are critical for the GTPase-activating mechanism
• contains 1 Rab-GAP TBC domain

Compartment

• localizes to the microvilli-rich region of syncytiotrophoblast
• in melanocytes, located at the periphery of cells

Alternative splicing

named isoforms=2

More general terms

• TBC1 domain family member

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83874
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83874
• OMIM: https://mirror.omim.org/entry/610020
• UniProt: http://www.uniprot.org/uniprot/Q9BXI6.html