V-type proton ATPase subunit B, kidney isoform; V-ATPase subunit B1; vacuolar proton pump subunit B1; endomembrane proton pump 58 kD subunit (ATP6V1B1, ATP6B1, VATB, VPP3)

Function

• non-catalytic subunit of peripheral V1 complex of vacuolar ATPase
• forms a complex with SLC9A3R1 & SCL4A7

Structure

• PDZ-binding motif mediates interactions with SLC9A3R1 & SCL4A7
• belongs to the ATPase alpha/beta chains family

Compartment

• intracytoplasmic membrane
• peripheral membrane protein
• endomembrane

Expression

expressed in the cochlea & endolymphatic sac

Pathology

• defects in ATP6V1B1 are the cause of distal renal tubular acidosis with deafness

More general terms

• vacuolar ATP synthase subunit B

Database

• UniProt: http://www.uniprot.org/uniprot/P15313.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=525
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:525
• OMIM: https://mirror.omim.org/entry/192132
• OMIM: https://mirror.omim.org/entry/267300