mu opioid receptor; MOR-1 (OPRM1, MOR1)
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Function
- receptor for beta-endorphin
- selectively sensitive to morphine
- binds enkephalins & endorphins
- inhibits neurotransmitter release by reducing Ca+2 currents & increasing K+ conductance
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
Alternative splicing
named isoforms=2
Polymorphism
- variant Asp-40
- binds beta-endorphin with 3-fold greater affinity than most common allelic form
- does not show altered binding affinities for most opioid peptides & alkaloids tested
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P35372.html
- ↑ Wikipedia; Note: Mu opioid receptor entry http://en.wikipedia.org/wiki/Mu_opioid_receptor
- ↑ VanDongen AM, Codina J, Olate J, Mattera R, Joho R, Birnbaumer L, Brown AM. Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. Science. 1988 Dec 9;242(4884):1433-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/3144040
- ↑ Harada H, Ueda H, Katada T, Ui M, Satoh M. Phosphorylated mu-opioid receptor purified from rat brains lacks functional coupling with Gi1, a GTP-binding protein in reconstituted lipid vesicles. Neurosci Lett. 1990 May 18;113(1):47-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2164175
- ↑ Reisine T, Bell GI. Molecular biology of opioid receptors. Trends Neurosci. 1993 Dec;16(12):506-10. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7509520