Lin-7 homolog B (Lin-7B, hLin7B, mammalian lin-seven protein 2, MALS-2, vertebrate lin-7 homolog 2, veli-2 protein, hVeli2, LIN7B, MALS2, VELI2, UNQ3116/PRO10200)

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Function

role in establishing & maintaining asymmetric distribution of channels & receptors at plasma membrane of polarized cells
forms membrane-associated multiprotein complexes that may regulate delivery & recycling of proteins to correct membrane domains
component of tripartite complex LIN7B/CASK/APBA1 complex with potential to couple synaptic vesicle exocytosis to cell adhesion in brain
ensures the proper localization of GRIN2B (subunit 2B of NMDA receptor) to neuronal postsynaptic density
role in localizing synaptic vesicles at synapses where it is recruited by beta-catenin & cadherin
required to localize Kir2 channels, GABA transporter (SLC6A12) & EGFR/ERBB1, ERBB2, ERBB3 & ERBB4 to the basolateral membrane of epithelial cells
may increase amplitude of ACCN3 acid-evoked currents by stabilizing channel at cell surface
forms two exclusive ternary complexes with CASK & APBA1 or CASKIN1
can also interact with other modular proteins containing protein-protein interaction domains, including MPP5, MPP6, DLG1, DLG2 & DLG3 through its L27 domain
interacts with DLG4, GRIN2B, CDH1, CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 & probably KCNJ2/Kir2.1, & SLC6A12/BGT-1 via its PDZ domain
association of LIN7A with cadherin & beta-catenin is Ca+2-dependent, occurs at synaptic junctions & requires actin cytoskeleton
interacts with EGFR, ERBB2, ERBB3 & ERBB4 with both PDZ & KID domains
asociates with KIF17 via APBA1
interacts with ACCN3.

belongs to the lin-7 family
contains 1 L27 domain mediates interaction with CASK role formation of multimeric complexes association of LIN7 to membranes
contains 1 PDZ domain (DHR domain) regulates endocytosis & recycling of receptor at membrane
kinase interacting site required for proper delivery of ERBB2 to the basolateral membrane