inwardly-rectifying K+ channel J2; K+ channel, inwardly rectifying subfamily J member 2; inward rectifier K+ channel Kir2.1; cardiac inward rectifier K+ channel; IRK1 (KCNJ2, HIRK1)

Function

• inwardly-rectifying K+ channel
• probably participates in establishing action potential waveform & excitability of neuronal & muscle tissues
• can be blocked by extracellular Ba+2 or Cs+2
• homomultimeric & heteromultimeric association with Kir2.3, resulting in an enhanced G-protein-induced current
• association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK & APBA1 plays a key role in its localization & trafficking (putative)
• cardiac inward rectifier

Structure

• belongs to the inward rectifier-type K+ channel family

Compartment

membrane

Expression

• heart, brain, placenta, lung, skeletal muscle, & kidney
• diffusely distributed throughout the brain

Pathology

• defects in KCNJ2 are the cause of
  • long QT syndrome type 7
  • short QT syndrome type 3

More general terms

• inwardly-rectifying K+ channel subfamily J

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3759
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3759
• OMIM: https://mirror.omim.org/entry/170390
• OMIM: https://mirror.omim.org/entry/600681
• OMIM: https://mirror.omim.org/entry/609622
• UniProt: http://www.uniprot.org/uniprot/P63252.html