Lin-7 homolog C; Lin-7C; mammalian lin-seven protein 3; MALS-3; vertebrate lin-7 homolog 3; Veli-3 protein (LIN7C, MALS3, VELI3)

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Function

role in establishing & maintaining asymmetric distribution of channels & receptors at the plasma membrane of polarized cells
forms membrane-associated multiprotein complexes that may regulate delivery & recycling of proteins to correct membrane domains
tripartite complex composed of LIN7C, CASK & APBA1 couple synaptic vesicle exocytosis to cell adhesion in brain (putative)
ensures proper localization of GRIN2B (NMDA receptor subunit 2B) to neuronal postsynaptic density
localizes synaptic vesicles at synapses where it is recruited by beta-catenin & cadherin
required to localize Kir2 channels, GABA transporter (SLC6A12) & EGFR/ERBB1, ERBB2, ERBB3 & ERBB4 to the basolateral membrane of epithelial cells
forms two exclusive ternary complexes with CASK & APBA1 or CASKIN1
interacts with other modular proteins containing protein- protein interaction domains including MPP5, MPP6, DLG1, DLG2 & DLG3 through its L27 domain
interacts with DLG4, GRIN2B, CDH1, CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 & probably KCNJ2/Kir2.1 & SLC6A12/BGT-1 via its PDZ domain
Ca+-dependent association of LIN7A with cadherin & beta-catenin at synaptic junctions requires actin cytoskeleton
interacts with EGFR, ERBB2, ERBB3 & ERBB4 with both PDZ & KID domains
associates with KIF17 via APBA1.

belongs to the lin-7 family
contains 1 L27 domain, mediates interaction with CASK & is involved in formation of multimeric complexes & the association of LIN7 to membranes
contains 1 PDZ domain (DHR domain), regulates endocytosis & recycling of receptor at cell membrane
kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane