ATP-sensitive inward rectifier K+ channel 12; K+ channel, inwardly rectifying subfamily J member 12; Inward rectifier K+ channel Kir2.2; Kir2.2v; IRK2 (KCNJ12, IRK2, KCNJN1)

Function

• inwardly rectifying K+ channel that probably participates in establishing action potential waveform & excitability of neuronal & muscle tissues
• can be blocked by extracellular Ba+2 & Cs+2
• association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK & APBA1 plays a key role in its localization & trafficking (putative)

Structure

• belongs to the inward rectifier-type K+ channel family

Compartment

membrane

More general terms

• inwardly-rectifying K+ channel subfamily J
• ATP-sensitive K+ channel (inwardly-rectifying K+ channel)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q14500.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100131
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100290
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3768
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:100131
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:100290
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3768
• OMIM: https://mirror.omim.org/entry/602323