ATP-sensitive K+ channel (inwardly-rectifying K+ channel)

Function

• inwardly rectifying K+ channel
• phosphorylation & subsequent ATP-binding close channel, depolarizing beta cell
• depolarization of beta cell linked to Ca+2 influx & insulin secretion

Structure

• Structure:
• between the two transmembrane domains is an exoplasmic loop (H5 region) containing the pore-forming region

More general terms

• inwardly-rectifying K+ channel
• phosphoprotein

More specific terms

• ATP-sensitive inward rectifier K+ channel 12; K+ channel, inwardly rectifying subfamily J member 12; Inward rectifier K+ channel Kir2.2; Kir2.2v; IRK2 (KCNJ12, IRK2, KCNJN1)
• ATP-sensitive inward rectifier K+ channel 15; K+ channel, inwardly rectifying subfamily J member 15; inward rectifier K+ channel Kir4.2; Kir1.3 (KCNJ15 KCNJ14)
• inwardly-rectifying K+ channel J10; ATP-sensitive inward rectifier K+ channel 10; K+ channel, inwardly rectifying subfamily J member 10; inward rectifier K+ channel Kir1.2; ATP-dependent inwardly rectifying K+ channel Kir4.1 (KCNJ10)
• inwardly-rectifying K+ channel J11; ATP-sensitive inward rectifier K+ channel 11; K+ channel, inwardly rectifying subfamily J member 11; inward rectifier K+ channel Kir6.2; IKATP (KCNJ11)
• inwardly-rectifying K+ channel J1; ATP-sensitive inward rectifier K+ channel 1; K+ channel, inwardly rectifying subfamily J member 1; ATP-regulated K+ channel ROM-K; Kir1.1 (KCNJ1, ROMK1)
• inwardly-rectifying K+ channel J8; ATP-sensitive inward rectifier K+ channel 8; K+ channel, inwardly rectifying subfamily J member 8; inwardly rectifier K+ channel Kir6.1; uKATP-1 (KCNJ8)

Components

• sulfonylurea receptor 2; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette C9 (ABCC9, SUR2)
• sulfonylurea receptor 1; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette C8 (ABCC8, HRINS, SUR SUR1)