sulfonylurea receptor 1; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette C8 (ABCC8, HRINS, SUR SUR1)
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Function
- putative subunit of the beta-cell ATP-sensitive K+ channel (KATP)
- regulator of ATP-sensitive K+ channels & insulin release
- associates with KCNJ11
- because of the presence of 2 ATP-binding cassettes, the sulfonylurea receptor may not function physiologically as a receptor, but may sense ATP/ADP status of beta cells, thus modifiying K+ channel activity & insulin release
Structure
- belongs to the ABC transporter family, conjugate
- transporter (TC 3.A.1.208) subfamily
- contains 2 ABC transmembrane type-1 domains
- contains 2 ABC transporter domains
Compartment
membrane
Alternative splicing
named isoforms=2
Pathology
- defects in ABCC8 are a cause of
- defects in ABCC8 may contribute to diabetes mellitus type 2 in Northern European Caucasians
Pharmacology
- sulfonylureas represent a class of drugs used clinically to promote insulin secretion in the treatment of type 2 diabetes
- these drugs interact with the sulfonylurea receptor of pancreatic beta cells & inhibit the conductance of ATP-dependent K+ channels
More general terms
- transmembrane 13 protein
- phosphoprotein
- cell surface receptor
- ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
Additional terms
- ATP-sensitive K+ channel (inwardly-rectifying K+ channel)
- inwardly-rectifying K+ channel J11; ATP-sensitive inward rectifier K+ channel 11; K+ channel, inwardly rectifying subfamily J member 11; inward rectifier K+ channel Kir6.2; IKATP (KCNJ11)
- sulfonylurea
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q09428.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ABCC8
- ↑ Raab-Graham KF et al Membrane topology of the amino-terminal region of the sulfonylurea receptor J Biol Chem. 1999 Oct 8;274(41):29122-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10506167
- ↑ Aguilar-Bryan L et al Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science. 1995 Apr 21;268(5209):423-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716547
Database
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6833
- OMIM: https://mirror.omim.org/entry/240800
- OMIM: https://mirror.omim.org/entry/256450
- OMIM: https://mirror.omim.org/entry/600509
- OMIM: https://mirror.omim.org/entry/602485
- OMIM: https://mirror.omim.org/entry/606176
- OMIM: https://mirror.omim.org/entry/610374
- UniProt: http://www.uniprot.org/uniprot/Q09428.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6833