inwardly-rectifying K+ channel J11; ATP-sensitive inward rectifier K+ channel 11; K+ channel, inwardly rectifying subfamily J member 11; inward rectifier K+ channel Kir6.2; IKATP (KCNJ11)

Function

• inwardly-rectifying K+ channel controlled by G proteins
• can be blocked by extracellular Ba+2 (putative)
• associates with the sulfonylurea receptor SUR2 & SUR2B
• associates with ABCC8/SUR

Structure

• belongs to the inward rectifier-type K+ channel family

Compartment

membrane

Pathology

• defects in KCNJ11 are the cause of
  • familial hyperinsulinemic hypoglycemia type 2
  • transient neonatal diabetes mellitus type 3
• defects in KCNJ11 are a cause of
  • permanent neonatal diabetes mellitus
• defects in KCNJ11 may contribute to diabetes mellitus type 2

More general terms

• inwardly-rectifying K+ channel subfamily J
• ATP-sensitive K+ channel (inwardly-rectifying K+ channel)

Additional terms

• sulfonylurea receptor 1; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette C8 (ABCC8, HRINS, SUR SUR1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q14654.html
• OMIM: https://mirror.omim.org/entry/600937
• OMIM: https://mirror.omim.org/entry/256450
• OMIM: https://mirror.omim.org/entry/601820
• OMIM: https://mirror.omim.org/entry/602485