inwardly-rectifying K+ channel J1; ATP-sensitive inward rectifier K+ channel 1; K+ channel, inwardly rectifying subfamily J member 1; ATP-regulated K+ channel ROM-K; Kir1.1 (KCNJ1, ROMK1)

Function

• inwardly-rectifying K+ channel
• in the kidney, probably plays a major role in K+ homeostasis
• channel is activated by internal ATP & can be blocked by external Ba+2

Structure

• belongs to the inward rectifier-type K+ channel family

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed kidney & pancreatic islets
• lower levels in skeletal muscle, pancreas, spleen, brain, heart & liver

Pathology

• defects in KCNJ1 are the cause of Bartter syndrome type-2

More general terms

• inwardly-rectifying K+ channel subfamily J
• ATP-sensitive K+ channel (inwardly-rectifying K+ channel)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3758
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3758
• OMIM: https://mirror.omim.org/entry/241200
• OMIM: https://mirror.omim.org/entry/600359
• UniProt: http://www.uniprot.org/uniprot/P48048.html