sulfonylurea receptor 2; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette C9 (ABCC9, SUR2)

Function

• subunit of ATP-sensitive K+ channels (KATP)
• can form cardiac & smooth muscle-type KATP channels with KIR6.2; KIR6.2 forms the channel pore while SUR2 is required for activation & regulation

Structure

• belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily
• contains 2 ABC transmembrane type-1 domains
• contains 2 ABC transporter domains

Compartment

membrane (potential)

Alternative splicing

named isoforms=2

Pathology

• defects in ABCC9 are the cause of dilated cardiomyopathy 1O

More general terms

• transmembrane 15 protein
• ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
• phosphoprotein
• cell surface receptor
• glycoprotein

Component of

• ATP-sensitive K+ channel (inwardly-rectifying K+ channel)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10060
• OMIM: https://mirror.omim.org/entry/601439
• OMIM: https://mirror.omim.org/entry/608569
• UniProt: http://www.uniprot.org/uniprot/O60706.html