Na+ & chloride-dependent GABA transporter 1; GAT-1; solute carrier family 6 member 1 (SLC6A1, GABATR, GABT1, GAT1)

Function

• terminates the action of GABA by its high affinity
• Na+-dependent reuptake into presynaptic terminals
• interacts with MPP5 (putative)

Structure

• the PDZ domain-binding motif is involved in the
• interaction with MPP5
• belongs to the Na+:neurotransmitter symporter (SNF) family

Compartment

• cell membrane
• localized at plasma membrane & in a subset of intracellular vesicles
• localized at the presynaptic terminals of interneurons

Pharmacology

• SLC6A1 is the target of psychomotor stimulants such as amphetamines or cocaine

More general terms

• solute carrier family 6

Database

• OMIM: https://mirror.omim.org/entry/137165
• UniProt: http://www.uniprot.org/uniprot/P30531.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6529